Mission Hill follows 24-year-old retail employee Andy French (Wallace Langham) whose life dramatically changes when he takes in his 17-year-old brother Kevin (Scott Menville) when their parents pick up and move to Wyoming. The two brothers live with Andy’s roommates Jim Kuback (Brian Posehn) and Posey Tyler (Vicki Lewis) in the city’s neighborhood that bears the name of the show.
Andy’s slacker nature counters the enthusiasm and nerdish qualities of his younger brother. Kevin is socially awkward, sheltered, and a certified genius. The two continually butt heads episode after episode, with asides from the stoic Jim and the pseudo-hippie Posey’s musings often helping to resolve their issues.