Researchers develop new genetic model to decode breast cancer
A team of US researchers has developed a new genetic model for breast cancer that could help scientists better understand why and where cancer metastasises.
Professor Eran Andrechek from Michigan State University in the US has been researching the E2F5 gene and its role in the development of breast cancer.
Based on findings from Andrechek’s lab, the loss of E2F5 results in altered regulation of Cyclin D1, a protein linked to metastatic breast tumours after long latency.
The study, published in the journal Oncogene, also demonstrated that the removal of E2F5 in the mammary gland leads to tumour formation.
As scientists better understand how genes impact breast cancer, they could also learn why cancers metastasize and where cancers are likely to spread.
According to Andrechek, while a ...










