New nasal drug delivery method can reduce TB bacteria in brain by 1,000 times
In a first, scientists at the Institute of Nano Science and Technology (INST), Mohali, an autonomous institute of the Department of Science and Technology (DST) have developed a unique way through the nose to deliver tuberculosis (TB) medicines directly to the brain.
TB that affects the brain is called Central Nervous System Tuberculosis (CNS-TB) and is one of the most dangerous forms of TB, often leading to severe complications or death.
The novel nose-to-brain (N2B) drug delivery utilises the olfactory and trigeminal nerve pathways in the nasal cavity and effectively bypasses the challenging blood-brain barrier (BBB).
While traditional treatments involve high doses of oral anti-TB drugs, they often fail to achieve effective concentrations in the cerebrospinal fluid as the BBB limits ...










